Dopaminergic regulation of avian prolactin gene transcription

Transcription and post-transcriptional regulation of avian HSP70 gene expression.

Transient incubation of chicken lymphoblastoid (MSB) cells at elevated temperatures induces the synthesis of three heat shock proteins of 89,000 Da (HSP89), 70,000 Da (HSP70), and 23,000 Da (HSP23). We have examined the effects of heat shock on the transcription and post-transcriptional regulation of the chicken HSP70 and beta-actin genes. The rate of HSP70 transcription is rapidly induced by h...

The Prolactin Gene: A Paradigm of Tissue-Specific Gene Regulation with Complex Temporal Transcription Dynamics

Transcription of numerous mammalian genes is highly pulsatile, with bursts of expression occurring with variable duration and frequency. The presence of this stochastic or 'noisy' expression pattern has been relatively unexplored in tissue systems. The prolactin gene provides a model of tissue-specific gene regulation resulting in pulsatile transcription dynamics in both cell lines and endocrin...

Dopaminergic control of prolactin and blood pressure.

Glucose regulation of gene transcription.

Nutrient gene regulation is an important adaptation allowing survival on intermittent food supplies. This adaptative process exists in all species from yeast to mammals. Glucose, the most abundant monosaccharide in nature, provides a very good example of how organisms have developed regulatory mechanisms to cope with a fluctuating level of nutrient supply. In yeast, glucose facilitates its own ...

Regulation of ribosomal gene transcription.

In eukaryotic cells, ribosomal RNA (rRNA) gene is transcribed by RNA polymerase I (pol I) in the nucleolus as a large (40 S-47 S) precursor RNA (pre-rRNA) (for reviews, see refs. [1,2]). The mature rRNA species (28 S, 18 S and 5.8 S) are formed after a series of specific endonucleolytic cleavage reactions (for a review, see ref. [3]). The rRNA gene (rDNA) is highly reiterated and is arranged in...